Rosacea Review - Newsletter of the National Rosacea SocietyRosacea Review - Newsletter of the National Rosacea Society

New Research Grants Awarded to Further Knowledge of Rosacea

The National Rosacea Society (NRS) has awarded five new research grants to advance scientific knowledge of the potential causes and other key aspects of this chronic and potentially devastating disorder that affects an estimated 14 million Americans.

"We are very pleased that a growing number of high-quality research proposals are now being received," said Dr. Jonathan Wilkin, chairman of the Society's medical advisory board, which reviews each grant application and selects for funding those believed most likely to yield important results.

The research grants are supported by individual donations, and readers are encouraged to help expand this vital program by sending contributions using the donation form inside.

Dr. Martin Steinhoff, department of dermatology, University of Muenster, Germany, and colleagues were awarded a $25,000 grant. They hypothesize that a protein known as endothelin-converting enzyme-1 (ECE-1) may regulate vascular function and nerve-caused inflammation in the skin, and thus be involved in the pathophysiology of rosacea. The study aims to define the expression and distribution of the four ECE-1 isoforms in both normal and rosacea tissue, which may lead to new strategies to treat rosacea.

Dr. Richard Granstein, chairman of dermatology at Cornell University, and colleagues received a research grant of $25,000. In past research, Dr. Granstein and colleagues found that substances that activate endothelial cells through the P2 cell receptors cause the release of factors that recruit and promote inflammation. In the new proposal, they will study which P2 receptors are affected, and whether inhibiting these substances in vitro may facilitate the discovery of new treatments for rosacea.

Dr. Richard Gallo, chief of the division of dermatology at the University of California-San Diego, and Dr. Kenshi Yamasaki of the Veterans Medical Research Foundation also received a $25,000 grant. In earlier studies, they discovered that individuals with rosacea have too much of a type of natural antibiotic called cathelicidins, and plan to use animal models and artificial cell culture techniques to further examine the function and activity of cathelicidin-processing enzymes in rosacea skin. If successful, the experiments may show that abnormal regulation of cathelicidin production leads to rosacea, leading to completely new therapeutic approaches.

Dr. Payam Tristani-Firouzi, assistant professor, and Dr. Nancy Samolitis, visiting professor, department of dermatology, University of Utah, were awarded $23,600 to examine the effect of pulse dye laser (PDL) and intense pulsed light (IPL) treatment of rosacea to determine whether, in addition to reducing the amount of blood vessels, these procedures produce structural and biologic changes in the skin. The Rosacea Research Foundation donated $16,065 to the NRS toward the funding of this study.

They will visually and microscopically assess the primary features of rosacea before and after treatment with PDL and IPL, including redness, visible blood vessels, and bumps and pimples. In addition, biopsy samples before and after treatment will be tested for factors that play a potential role in rosacea, including inflammatory cells, vascular endothelial growth factor (VEGF) and others.

They will also assess the size of the oil glands and the presence of Demodex mites, normal inhabitants of human skin that have been observed in greater numbers in rosacea patients. The study will include 10 patients with subtype 1 (erythematotelangiectatic) and subtype 2 (papulopustular) rosacea, each receiving treatment on one side of the face, with the other side serving as a control.

Dr. Yaxian Zhen and Dr. Albert Kligman, department of dermatology, University of Pennsylvania, will receive $25,000 to develop objective, quantitative assessments of rosacea using a variety of equipment. They note that these noninvasive methods would provide a means to measure the presence and severity of rosacea's known symptoms, perhaps identify others, and gauge their presence and severity after treatment.

The instrumentation includes scanning laser Doppler imaging, optical coherence tomography, confocal microscopy, specialized digital photography, colorimetry by chromometer and surface (nonsurgical) biopsy. Skin hydration would be measured via an electrical conductance device and a capacitance measuring device, and the skin's topography studied by a fringe projection device.